Benjamin Edwards was a minor figure on the Stephen H. Long Expedition to the Rocky Mountains. His six letters addressed to his father Oliver Edwards briefly mention the expedition, including his attempts to collect pay for his part in the expedition. His letters also discuss his life in Louisiana after the expedition working on the Steamboat Hope and later as overseer of slaves in a sawmill.

An extensive family collection, the Vaux Family Papers center around the lives of George Vaux V (1721-1803), George Vaux VII (1779-1836), and George Vaux VIII (1832-1915), their business partners, siblings, wives, and children, and encompasses the extended Vaux family of Warders, Sansoms, Heads, Graffs, Morrises, Cressons, and Mayberrys. The collection includes correspondence, financial accounts, receipts, business records, journals, diaries, photographs, and legal documents.

Through his craniometic studies of human races, the Philadelphia physician Samuel George Morton (1799-1851) exerted a profound influence on the development of physical anthropology in antebellum America, and made substantial contributions to mineralogy, paleontology, and natural history. Relating primarily to Morton's scientific interests, the Morton Papers include insights into Morton's perspectives on education, medical practice, geology and mineralogy, craniology, paleontology, the Wilkes Exploring Expedition (also known as the United States Exploring Expedition 1838-1842), and his two major monographs, the Crania Americana and Crania Aegyptiaca. Several of the letters were written by Morton in his capacity as corresponding secretary of the Academy of Natural Sciences of Philadelphia. Also included in this collection are Morton's "Some Remarks on the Infrequency of Mixed Offspring Between the European and Australian Races" (1850), Joseph Barclay Pentland's notes on the aborigines of Peru (ca. 1840?), and newspaper clippings on Morton's death; a diary of Morton's trip to the West Indies, 1834, a set of craniological sketches for use in Crania Americana, and a microfilm of letters in private hands, written to Morton, 1838-1844

This is a collection of letters, letterbooks, account books, scrapbooks, etc., concerning the families of Robert Hare and Thomas Willing. The letters and other documents include early family material, as well as documents written by numerous family relations, and some obviously only collected by them. The Willing family letters (1744-1901) are diverse, concerning family matters, business, society, comments on the Civil War, etc. There are numerous letters from Thomas Willing, many concerning his banking career, as President of the Bank of North America and later at the first Bank of the U.S. The Hare family letters (1724-1965) are more extensive and diverse, including much on travel in the U.S. and elsewhere. There is a letter from Robert Hare Jr. concerning steam engines, and letters from Horace Binney Hare concerning his education at Harvard, 1860, his trip to San Francisco and the west, 1862, and numerous letters written while a soldier in the Civil War. There are many letters from Horace Binney (1780-1875, DAB) to his daughter Esther, who was married to John Innes Clark Hare (1816-1905, DAB), concerning family travel and court cases. There are also letters from outside the family, such as those from Dorothea L. Dix. The bound volumes include, among others: Robert Hare letterbooks (1824-1825, 1841-1857), estate records, and laboratory expense accounts (1818-1860); G. H. Hare's journal or log of cruises aboard the U.S. United States (1841) and U.S. Flint (1845); Horace Binney Hare's 1862 journal of his trip to San Francisco. There are account books and accounts (1754-1795) kept by Thomas Willing; accounts of the controversy over the estate of John Innes Clark; and records of the First Colored Wesley Methodist Church of Philadelphia (receipt book, 1820-1848; minute book, 1827-1844). There are also Philadelphia court records, and minutes of the Common Council of the city, 1832.